![]() American Physiological Society, Washington, DC Rahn H, Fenn WO (1955) A graphical analysis of the respiratory gas exchange. ![]() J Clin Invest 54:54–68Įvans JW, Wagner PD (1977) Limits on VA/Q distributions from analysis of experimental inert gas elimination. Wagner PD, Laravuso RB, Uhl RR, West JB (1974) Continuous distributions of ventilation–perfusion ratios in normal subjects breathing air and 100% O 2. Wagner PD, Naumann PF, Laravuso RB (1974) Simultaneous measurement of eight foreign gases in blood by gas chromatography. Wagner PD, Saltzman HA, West JB (1974) Measurement of continuous distributions of ventilation–perfusion ratios: theory. West JB (2008) Pulmonary pathophysiology – the essentials. An overview of the technical details of implementing MIGET is given, and the review ends with potential future applications. It is noted that in addition to quantifying ventilation/perfusion inequality and pulmonary shunting, MIGET can identify and quantify diffusion limitation of O 2 exchange, when present, as well as explain the contributions of extrapulmonary influences such as inspired O 2 concentration, ventilation, cardiac output, Hb concentration/P 50, body temperature and acid/base state on arterial oxygenation. After a brief history of MIGET, its principles are laid out, its information content is explained, and its limitations are described. MIGET is based on the very same mass-conservation principles underlying the classic work of Rahn and Fenn and of Riley and coworkers in the 1950s, which defines the relationship between the ventilation/perfusion ratio and the alveolar and capillary partial pressures of any gas. It then uses those measurements to compute the distribution of ventilation/perfusion ratios that best explains the exchange of the six gases simultaneously. ![]() This technique, developed in the 1970s, measures the pulmonary exchange of a set of six different inert gases dissolved together in saline (or dextrose) and infused intravenously. This brief review centers on the multiple inert gas elimination technique (MIGET). ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |